A New Route to 7-Dehydrocholesterol, Provitamin D3
نویسندگان
چکیده
منابع مشابه
Provitamin D3 in tissues and the conversion of cholesterol to 7-dehydrocholesterol in vivo.
The discovery that the absorption bands at 293, 281-5 and 271 m,u. (Heilbron, Kamm & Morton, 1926, 1927) present in fractions obtained in the recrystallization of cholesterol were shown very strongly by ergosterol (Rosenheim & Webster, 1927) focused interest on the latter and culminated in the isolation ofcalciferol (vitamin D2). Some time later it was recognized that 7-dehydrocholesterol was a...
متن کاملBinding of 7-dehydrocholesterol to sterol carrier protein and vitamin D3 effect.
It was confirmed that delta 5,7-sterol delta 7-reductase activity was suppressed by cholecalciferol (vitamin D3) in the enzyme system consisted of microsomes and sterol carrier protein (SCP). The enzyme activity was significantly decreased in the combination with microsomes obtained from either vitamin D-deficient or vitamin D3-treated rat liver and with SCP obtained from vitamin D3-treated rat...
متن کاملIsolation and identification of 24-dehydroprovitamin D3 and its photolysis to 24-dehydroprevitamin D3 in mammalian skin.
Until now it had been assumed that mammalian skin contains only one provitamin D, 7-dehydrocholesterol, that is eventually converted to vitamin D3 after the skin is exposed to sunlight. Examination by reverse phase high performance liquid chromatography of lipid extracts from young rat skin, however, led to the observation that 7-dehydrocholesterol is not the only provitamin D in rat skin. Anot...
متن کاملThe "d" Vitamins
In a classical sense, vitamin D3, the form produced in animals, is not a true “vitamin” because it is produced in the skin from 7-dehydrocholesterol by UV radiation in the range 290 to 300 nm; 7-dehydrocholesterol is produced from cholesterol metabolism. Only when exposure to sunlight is inadequate does vitamin D3 become a vitamin in the historical sense. Further, vitamin D3 is now termed a pro...
متن کاملA new facile route to synthesize thieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidine derivatives
A new facile route for synthesis of 3- (aryl) -8, 9- di (alkyl) thieno [3,2-e] [1,2,4] triazolo pyrimidines derivative from the same starting material, 2- amino - 4,5 -di (alkyl) thiophene-3- carboxamide, has been developed through heterocyclization of the corresponding arylidene-hydrazino -5,6 -di (alkyl) thieno [2,3-d] pyrimidine under refluxing condition with acetic anhydride followed by air...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature
سال: 1946
ISSN: 0028-0836,1476-4687
DOI: 10.1038/158169a0